Electric Fields Accelerate CRISPR-based COVID Test

The world desperately needs a portable, reliable COVID-19 test that can deliver immediate results. Now scientists at Stanford University say they hope that a new diagnostic assay will fill that void.

In a paper published last week in the journal PNAS, the scientists describe how they used electric fields and the genetic engineering technique CRISPR to build a microfluidic lab-on-a-chip that can detect the novel coronavirus. The test delivers results in about half an hour—a record for CRISPR-based assays, according to the authors—and uses a lower volume of scarce reagents, compared with other CRISPR-based tests in development.

“We’re showing that we have all the elements required to achieve a miniaturized and automated device with no moving parts,” says Juan Santiago, vice chair of mechanical engineering at Stanford, who led the research. He adds, however, that more work lies ahead before their test could be ready for the public.  

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